Endocrine Abstracts

Background: Environmental rhythmicity seems able to affect the hypothalamic-pituitary-gonadal axis in animals to achieve reproductive advantages. However, conflicting results were obtained when assessing the environmental-dependent rhythmicity on reproductive hormone secretion in humans.Aim of the study: This study was designed to evaluate seasonal fluctuations of the main hormones involved in the hypothalamic-pituitary-gonadal axis in men, using a big d...

Background: Metabolic dysfunction associated fatty liver disease (MAFLD), the leading cause of chronic liver disease, is defined as the presence of hepatic steatosis and metabolic risk factors. Both testosterone and estradiol seem to have a pivotal role in hepatic lipid homeostasis, although underlying mechanisms are still unclear. Low testosterone serum levels result independently associated with MAFLD, but no studies so far evaluated MAFLD prevalence and severity in hypogona...